4M66 Chain B
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Inactive — 2.2%DFG-inαC-in
Resolution
2.4 Å
R-value
0.217
Predicted activity confidence2.2%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQLAYLDPELLFLKASKASDVYSFGILVWAVLAGREAELVQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQH
UniProt reference sequence
LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE
Aligned reference sequence
LENQ----------------ELVGKGG----------------FGTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--WDQDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGLSTFQGGSQSG--TGS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPELFVN--VN----------------------------RKAS-TASDVYSFGILMWAVLAG-------------------------REVELP------------------------------------------TEPSLVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKKL----------------EFVGKGG----------------FGVVFRAHH--RT------------------------------------WNHDVAVKIVN------------------------------------SKKISWEVKAMVNL--------------------------RNENVLLLLGVTEDLQ--WDFVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQALVTRFMEN--------------GSLAGLLQP--EA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLQEVVLGMCYLHSL--DP-----------------------------------------PLLHRDL-----KPSNILLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHAKLADFGLSTFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAYLDPEL-----LF----------------------------LKAS-KASDVYSFGILVWAVLAG-------------------------REAEL-------------------------------------------------------V--QSRPPLTELPPGSPETPGL--------------------------------------------------------------------------------------------EKLKELMIHCWGSQSENRPS--------------FQDCEPKTNE
Activation segment
DFGLSTFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAYLDPE
Binding pocket
EFVGKGGFGVVFRVAVKIVKISWEVKAMVNLRENVLLLLGVALVTRFMENGSLAGLLQPHSLDPPLLHRDLKPSNILLLADFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4M66, Chain B