4LL0 Chain B
Epidermal growth factor receptor (EGFR)
Inactive — 19.0%DFG-inαC-inType1 · YUN
Resolution
4.0 Å
R-value
0.238
Predicted activity confidence19.0%
Structure info
Alternate conformation—
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
APNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDEVDADEYL
UniProt reference sequence
FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
Aligned reference sequence
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLITQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGLAKLLGAEEKE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGGKVPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKKI----------------KVLGSGA----------------FGTVYKGLW--IPEGEK--------------------------------VKIPVAIKELR--EATSPKA---------------------------NKEILDEAYVMASV--------------------------DNPHVCRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLIMQLMPF--------------GCLLDYVRE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQYLLNWCVQIAKGMNYLEDR---------------------------------------------RLVHRDL-----AARNVLVKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHVKITDFGRAKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALESILH--------------------------------RIYT-HQSDVWSYGVTVWELMTF--G--------------SKPYDG--------------------------------------------------IPASEISSILEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK--------------FRELIIEFSK
Activation segment
DFGRAKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGRA
Ligand info
Orthosteric ligand
YUN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4LL0, Chain B