4LG4 Chain D
Serine/threonine-protein kinase 3 (STK3)
Inactive — 0.0%DFG-outαC-in
Resolution
2.42 Å
R-value
0.194
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VFDVLEKLGEGGSVFKAIHKVVAIKQDLQEIIKEISIMQQCDSPYVVKYYGSYFKWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE
UniProt reference sequence
FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI
Aligned reference sequence
FDVL----------------EKLGEGS----------------YGSVFKAIH--KE------------------------------------SGQVVAIKQVP--VESD------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYFKNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLWIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRDI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLADFGVAGQLTDTMAK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTVIGTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDVL----------------EKLGEG------------------GSVFKAIH--K----------------------------------------VVAIKQ-------D------------------------------LQEIIKEISIMQQC--------------------------DSPYVVKYYGSYFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WIVMEYCGA--------------GSVSDIIRL--RNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM---------------------------------------------RKIHRNI-----KAGNILLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAKLAD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPFWMAPEVIQE--------------------------------IGYN-CVADIWSLGITSIEMAEG-----------------KPPYAD--------------------------------------------------IHPMRAIFMIPTN--PPPTFRKPELWS---------------------------------------------------------------------------------------------------DDFTDFVKKCLVKNPEQRAT--------------ATQLLQHPFI
Activation segment
D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPFWMAPE
Binding pocket
EKLGEG__GSVFKVAIKQ_EIIKEISIMQQCDPYVVKYYGSWIVMEYCGAGSVSDIIRLYLHFMRKIHRNIKAGNILLLAD____
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4LG4, Chain D