4KS8 Chain A
Serine/threonine-protein kinase PAK 6 (PAK6)
Active — 99.6%DFG-inαC-inType1 · B49
Resolution
1.95 Å
R-value
0.22
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI
UniProt reference sequence
LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
Aligned reference sequence
LDSY----------------VKIGEGS----------------TGIVCLARE--KH------------------------------------SGRQVAVKMMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHFNVVEMYKSYLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVLMEFLQG--------------GALTDIVSQ--V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ---------------------------------------------GVIHRDI-----KSDSILLTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPEVISR--------------------------------SLYA-TEVDIWSLGIMVIEMVDG-----------------EPPYFS--------------------------------------------------DSPVQAMKRLRDS--PPPKLKNSHKVS---------------------------------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT--------------AQELLDHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LDSY----------------VKIGEGS----------------TGIVCLARE--KH------------------------------------SGRQVAVKMMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHFNVVEMYKSYLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVLMEFLQG--------------GALTDIVSQ--V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ---------------------------------------------GVIHRDI-----KSDSILLTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPEVISR--------------------------------SLYA-TEVDIWSLGIMVIEMVDG-----------------EPPYFS--------------------------------------------------DSPVQAMKRLRDS--PPPKLKNSHKVS---------------------------------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT--------------AQELLDHPFL
Activation segment
DFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPE
Binding pocket
VKIGEGSTGIVCLVAVKMMLLFNEVVIMRDYQFNVVEMYKSWVLMEFLQGGALTDIVSQYLHAQGVIHRDIKSDSILLLSDFGFC
Ligand info
Orthosteric ligand
B49
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4KS8, Chain A