4KKH Chain A
Mitogen-activated protein kinase 10 (MAPK10)
Inactive — 0.0%DFG-inαC-inType1 · 1RQ
Resolution
2.0 Å
R-value
0.232
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQKQLDEREHTIEEWKELIYKEVMN
UniProt reference sequence
YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
Aligned reference sequence
YQNL----------------KPIGSGA----------------QGIVCAAYD--AV------------------------------------LDRNVAIKKLS--RPFQNQTH--------------------------AKRAYRELVLMKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELMD---------------ANLCQVIQM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFGLARTAGTSFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPEVILG--------------------------------MGYK-ENVDIWSVGCIMGEMVRH-----------------KILFPG--------------------------------------------------RDYIDQWNKVIEQ--LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA------------------------------------------------------------SQARDLLSKMLVIDPAKRIS--------------VDDALQHPYI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQNL----------------KPIGSGA----------------QGIVCAAYD--AV------------------------------------LDRNVAIKKLS--RPFQNQTH--------------------------AKRAYRELVLMKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELMD---------------ANLCQVIQM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFGLARTA--SFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPEVILG--------------------------------MGYK-ENVDIWSVGCIMGEMVRH-----------------KILFPG--------------------------------------------------RDYIDQWNKVIEQ--LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA------------------------------------------------------------SQARDLLSKMLVIDPAKRIS--------------VDDALQHPYI
Activation segment
DFGLARTA--SFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPE
Binding pocket
KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIISLLNVYLVMELMD_ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA
Ligand info
Orthosteric ligand
1RQ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4KKH, Chain A