4JXF Chain A
Serine/threonine-protein kinase PLK4 (PLK4)
Inactive — 0.0%DFG-inαC-outType1 · 631
Resolution
2.4 Å
R-value
0.255
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
CIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHESDVWSLGCMFYTLLIGRPPFVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSR
UniProt reference sequence
FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
Aligned reference sequence
FKVG----------------NLLGKGS----------------FAGVYRAES--IH------------------------------------TGLEVAIKMID--KKAMYKAGM-------------------------VQRVQNEVKIHCQL--------------------------KHPSILELYNYFEDSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVYLVLEMCHN--------------GEMNRYLKN--RVK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHSH---------------------------------------------GILHRDL-----TLSNLLLTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKIADFGLATQLKMPHEK--H---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTLCGTPNYISPEIATR--------------------------------SAHG-LESDVWSLGCMFYTLLIG-----------------RPPFDT--------------------------------------------------DTVKNTLNKVVLA--DYEMPSFLS------------------------------------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS--------------LSSVLDHPFM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKVG----------------NLLGKGS----------------FAGVYRAES--IH------------------------------------TGLEVAIKMID--KKAMYKAGM-------------------------VQRVQNEVKIHCQL--------------------------KHPSILELYNYFEDSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVYLVLEMCHN--------------GEMNRYLKN--RVK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHSH---------------------------------------------GILHRDL-----TLSNLLLTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKIADFGLATQLKMPH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESDVWSLGCMFYTLLIG-----------------RPPF------------------------------------------------------VKNTLNKVVLA--DYEMPSFLS------------------------------------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS--------------LSSVLDHPFM
Activation segment
DFGLATQLKMPH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
NLLGKGSFAGVYRVAIKMIRVQNEVKIHCQLKPSILELYNYYLVLEMCHNGEMNRYLKNYLHSHGILHRDLTLSNLLLIADFGLA
Ligand info
Orthosteric ligand
631
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4JXF, Chain A