4JDK Chain A
Serine/threonine-protein kinase PAK 4 (PAK4)
Active — 99.8%DFG-inαC-in
Resolution
2.4 Å
R-value
0.188
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGVCAQVSKEVPRRKLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRAAAELLKHPFLAKAGPPASIVPLMRQNR
UniProt reference sequence
LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
Aligned reference sequence
LDNF----------------IKIGEGS----------------TGIVCIATV--RS------------------------------------SGKLVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHENVVEMYNSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ---------------------------------------------GVIHRDI-----KSDSILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQVSKEVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPELISR--------------------------------LPYG-PEVDIWSLGIMVIEMVDG-----------------EPPYFN--------------------------------------------------EPPLKAMKMIRDN--LPPRLKNLHKVS---------------------------------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT--------------AAELLKHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LDNF----------------IKIGEGS----------------TGIVCIATV--RS------------------------------------SGKLVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHENVVEMYNSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ---------------------------------------------GVIHRDI-----KSDSILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGVCAQVSKEVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPELISR--------------------------------LPYG-PEVDIWSLGIMVIEMVDG-----------------EPPYFN--------------------------------------------------EPPLKAMKMIRDN--LPPRLKNLHKVS---------------------------------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRA---------------AAELLKHPFL
Activation segment
DFGVCAQVSKEVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPE
Binding pocket
IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYQENVVEMYNSWVVMEFLEGGALTDIVTHVLHAQGVIHRDIKSDSILLLSDFGVC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4JDK, Chain A