4J98 Chain A
Fibroblast growth factor receptor 2 (FGFR2)
Active — 86.6%DFG-inαC-in
Resolution
2.31 Å
R-value
0.19
Predicted activity confidence86.6%
Structure info
Alternate conformationA
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AGVSEYELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKQTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT
UniProt reference sequence
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Aligned reference sequence
LTLG----------------KPLGEGC----------------FGQVVMAEA--VGIDKDKPK-----------------------------EAVTVAVKMLK--DDATEKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLRA--RRPPGMEYSYDINRVPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMTFKDLVSCTYQLARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVMKIADFGLARDINNIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLMWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLG----------------KPLGEGA----------------FGQVVMAEA--VGIDKDKPK-----------------------------EAVTVAVKMLK--DDATEKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLRA--RRPPGMEYSYDINRVPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMTFKDLVSCTYQLARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVMKIADFGLARDINNIDYY--KQT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLMWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLARDINNIDYY--KQT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPE
Binding pocket
KPLGEGAFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLRAYLASQKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4J98, Chain A