4IWD Chain A
Hepatocyte growth factor receptor (MET)
Active — 68.0%DFG-inαC-inAllosteric,Type1 · 1JC
Resolution
1.99 Å
R-value
0.207
Predicted activity confidence68.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKESVHNKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHHHHH
UniProt reference sequence
LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
Aligned reference sequence
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKEYY--SVHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGAKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKE----SVHN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Activation segment
DFGLARDMYDKE----SVHN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWMALE
Binding pocket
EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFGLA
Ligand info
Orthosteric ligand
1JC
Allosteric ligand
None
Ligand typeAllosteric,Type1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4IWD, Chain A