4ITJ Chain B
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Inactive — 0.5%DFG-outαC-outType2 · 1HX
Resolution
1.8 Å
R-value
0.189
Predicted activity confidence0.5%
Structure info
Alternate conformationB
Missing atoms5
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
UniProt reference sequence
FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRP
Aligned reference sequence
FLES----------------AELDSGG----------------FGKVSLCFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMCYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNELREVDGTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKNGGTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------ICEQQLIMCIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLES----------------AELDSGG----------------FGKVSLAFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMAYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------IAEQQLIMAIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Activation segment
DLGLASFKMWSKLN--NEEHNEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLYYMAPE
Binding pocket
AELDSGGFGKVSLMIMKTVALLEEAKMMNRLRSRVVKLLGVSLVMEYMEKGNLMHVLKAYLHGKGVIHKDLKPENILVIADLGLA
Ligand info
Orthosteric ligand
1HX
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ITJ, Chain B