4ITH Chain B
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Inactive — 3.3%DFG-outαC-outType3 · RCM
Resolution
2.25 Å
R-value
0.222
Predicted activity confidence3.3%
Structure info
Alternate conformationA
Missing atoms16
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LNVIKMKSSDFLESAELKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
UniProt reference sequence
FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRP
Aligned reference sequence
FLES----------------AELDSGG----------------FGKVSLCFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMCYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNELREVDGTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKNGGTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------ICEQQLIMCIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLES----------------AEL----------------------KVSLAFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMAYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------IAEQQLIMAIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Activation segment
DLGLASFKMWSKLN--NEEHNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLYYMAPE
Binding pocket
AEL______KVSLMIMKTVALLEEAKMMNRLRSRVVKLLGVSLVMEYMEKGNLMHVLKAYLHGKGVIHKDLKPENILVIADLGLA
Ligand info
Orthosteric ligand
RCM
Allosteric ligand
None
Ligand typeType3
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ITH, Chain B