4IJP Chain A
Serine/threonine-protein kinase PRP4 homolog (PRPF4B)
Inactive — 36.1%DFG-inαC-inType1 · 1EH
Resolution
2.25 Å
R-value
0.25
Predicted activity confidence36.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDEREKVTVMSTINPTKDLLADLIQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE
UniProt reference sequence
YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI
Aligned reference sequence
YNVY----------------GYTGQGV----------------FSNVVRARD--NAR-----------------------------------ANQEVAVKIIR--NNELM-----------------------------QKTGLKELEFLKKL--NDADPD------------------DKFHCLRLFRHFYHKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEPLS---------------MNLREVLKK--YGKDV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLHIKAVRSYSQQLFLALKLLKRC---------------------------------------------NILHADI-----KPDNILVNE--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTILKLCDFGSASHVADNDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYLVSRFYRAPEIIIG--------------------------------KSYD-YGIDMWSVGCTLYELYTG-----------------KILFPG--------------------------------------------------KTNNHMLKLAMDL--KGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKV------------------------------------------HQLKDLLDQILMLDPAKRIS--------------INQALQHAFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YNVY----------------GYTGQGV----------------FSNVVRARD--NAR-----------------------------------ANQEVAVKIIR--NNELM-----------------------------QKTGLKELEFLKKL--NDADPD------------------DKFHCLRLFRHFYHKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEPLS---------------MNLREVLKK--YGKDV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLHIKAVRSYSQQLFLALKLLKRC---------------------------------------------NILHADI-----KPDNILVNE--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTILKLCDFGSASHVADNDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TP-LVSRFYRAPEIIIG--------------------------------KSYD-YGIDMWSVGCTLYELYTG-----------------KILFPG--------------------------------------------------KTNNHMLKLAMDL--KGKMPNKMIRKGVFKDQHFDQNLNFMYIEVD---EREKVTVMSTINPTKDLLADLI--QRLPEDQRKKV------------------------------------------HQLKDLLDQILMLDPAKRIS--------------INQALQHAFI
Activation segment
DFGSASHVADNDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TP-LVSRFYRAPE
Binding pocket
GYTGQGVFSNVVRVAVKIITGLKELEFLKKLNFHCLRLFRHCLVFEPLS_MNLREVLKKLLKRCNILHADIKPDNILVLCDFGSA
Ligand info
Orthosteric ligand
1EH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4IJP, Chain A