4IC8 Chain A
Mitogen-activated protein kinase 7 (MAPK7)
Inactive — 0.0%DFG-inαC-in
Resolution
2.8 Å
R-value
0.263
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms30
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LKARSFDVTFDVGDEYEIIETIGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDALTRERIKEAIVAEIEDFHA
UniProt reference sequence
YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
Aligned reference sequence
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEII----------------ETI---------------------GVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFG-----------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Activation segment
DFG-----------------M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
ETIG_____VVSSVAIKKIRTLRELKILKHFKDNIIAIKDIYVVLDLME_SDLHQIIHSYMHSAQVIHRDLKPSNLLVIGDFG__
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4IC8, Chain A