4I6B Chain A
Serine/threonine-protein kinase PLK2 (PLK2)
Active — 81.7%DFG-inαC-inType1 · 11G
Resolution
1.8 Å
R-value
0.234
Predicted activity confidence81.7%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDFH
UniProt reference sequence
YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF
Aligned reference sequence
YCRG----------------KVLGKGG----------------FAKCYEMTD--LT------------------------------------NNKVYAAKIIP--HSRVAKPHQ-------------------------REKIDKEIELHRIL--------------------------HHKHVVQFYHYFEDKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYILLEYCSR--------------RSMAHILKA--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ---------------------------------------------EILHRDL-----KLGNFFINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMELKVGDFGLAARLEPLEHR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTICGTPNYLSPEVLNK--------------------------------QGHG-CESDIWALGCVMYTMLLG-----------------RPPFET--------------------------------------------------TNLKETYRCIREA--RYTMPSSLL------------------------------------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS--------------LDDIIRHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSRG----------------KTLGKGG----------------FAKCYEMTD--LT------------------------------------NNKVYAAKIIP--HSRVSKPHQ-------------------------REKIDKEIELHRIL--------------------------HHKHVVQFYHYFEDKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYILLEYCSR--------------RSMAHILKA--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ---------------------------------------------EILHRDL-----KLGNFFINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMELKVGDFGLAARLEPLEHR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTICGTPNYLSPEVLNK--------------------------------QGHG-AESDIWALGCVMYTMLLG-----------------RPPFET--------------------------------------------------TNLKETYRSIREA--RYTMPSSLL------------------------------------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS--------------LDDIIRHDFF
Activation segment
DFGLAARLEPLEHR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTICGTPNYLSPE
Binding pocket
KTLGKGGFAKCYEYAAKIIKIDKEIELHRILHKHVVQFYHYYILLEYCSRRSMAHILKAYLHEQEILHRDLKLGNFFIVGDFGLA
Ligand info
Orthosteric ligand
11G
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4I6B, Chain A