4I5M Chain A
Serine/threonine-protein kinase PLK2 (PLK2)
Inactive — 8.4%DFG-inαC-inType1 · R78
Resolution
1.8 Å
R-value
0.324
Predicted activity confidence8.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLETPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDF
UniProt reference sequence
YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF
Aligned reference sequence
YCRG----------------KVLGKGG----------------FAKCYEMTD--LT------------------------------------NNKVYAAKIIP--HSRVAKPHQ-------------------------REKIDKEIELHRIL--------------------------HHKHVVQFYHYFEDKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYILLEYCSR--------------RSMAHILKA--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ---------------------------------------------EILHRDL-----KLGNFFINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMELKVGDFGLAARLEPLEHR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTICGTPNYLSPEVLNK--------------------------------QGHG-CESDIWALGCVMYTMLLG-----------------RPPFET--------------------------------------------------TNLKETYRCIREA--RYTMPSSLL------------------------------------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS--------------LDDIIRHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSRG----------------KTLGKGG----------------FAKCYEMTD--LT------------------------------------NNKVYAAKIIP--HSRVSKPHQ-------------------------REKIDKEIELHRIL--------------------------HHKHVVQFYHYFEDKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYILLEYCSR--------------RSMAHILKA--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ---------------------------------------------EILHRDL-----KLGNFFINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMELKVGDFGLAARLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPNYLSPEVLNK--------------------------------QGHG-AESDIWALGCVMYTMLLG-----------------RPPFET--------------------------------------------------TNLKETYRSIREA--RYTMPSSLL------------------------------------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS--------------LDDIIRHDFF
Activation segment
DFGLAARLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPNYLSPE
Binding pocket
KTLGKGGFAKCYEYAAKIIKIDKEIELHRILHKHVVQFYHYYILLEYCSRRSMAHILKAYLHEQEILHRDLKLGNFFIVGDFGLA
Ligand info
Orthosteric ligand
R78
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4I5M, Chain A