4I0R Chain A
Tyrosine-protein kinase SYK (SYK)
Active — 99.8%DFG-inαC-inType1 · 1B4
Resolution
2.1 Å
R-value
0.237
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VYLDRKLLTLEDELGSGTVKKGYYQMKKVVKTVAVKILKPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNEGHH
UniProt reference sequence
LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN
Aligned reference sequence
LTLE--D-------------KELGSGN----------------FGTVKKGYY--QMKK----------------------------------VVKTVAVKILK--NEANDPAL--------------------------KDELLAEANVMQQL--------------------------DNPYIVRMIGICEAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWMLVMEMAEL--------------GPLNKYLQQ--NR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVKDKNIIELVHQVSMGMKYLEES---------------------------------------------NFVHRDL-----AARNVLLVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHYAKISDFGLSKALRADENY--YKAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THGKWPVKWYAPECINY--------------------------------YKFS-SKSDVWSFGVLMWEAFSY--G--------------QKPYRG--------------------------------------------------MKGSEVTAMLEKG--ERMGCPAGCP-----------------------------------------------------------------------------------------------------REMYDLMNLCWTYDVENRPG--------------FAAVELRLRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLE--D--------------ELGS-------------------GTVKKGYY--QMKK----------------------------------VVKTVAVKILK-------PAL--------------------------KDELLAEANVMQQL--------------------------DNPYIVRMIGICEAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWMLVMEMAEL--------------GPLNKYLQQ--NR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVKDKNIIELVHQVSMGMKYLEES---------------------------------------------NFVHRDL-----AARNVLLVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHYAKISDFGLSKALRADENY--YKA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWPVKWYAPECINY--------------------------------YKFS-SKSDVWSFGVLMWEAFSY--G--------------QKPYRG--------------------------------------------------MKGSEVTAMLEKG--ERMGCPAGCP-----------------------------------------------------------------------------------------------------REMYDLMNLCWTYDVENRPG--------------FAAVELRLRN
Activation segment
DFGLSKALRADENY--YKA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWPVKWYAPE
Binding pocket
_ELGSG___TVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS
Ligand info
Orthosteric ligand
1B4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4I0R, Chain A