4HZS Chain D
Activated CDC42 kinase 1 (TNK2)
Inactive — 0.0%DFG-inαC-out
Resolution
3.23 Å
R-value
0.247
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSV
UniProt reference sequence
LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE
Aligned reference sequence
LRLL----------------EKLGDGS----------------FGVVRRGEW--DAPSG---------------------------------KTVSVAVKCLK--PDVLSQPEA-------------------------MDDFIREVNAMHSL--------------------------DHRNLIRLYGVVLTP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMKMVTELAPL--------------GSLLDRLRK--HQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFLLGTLSRYAVQVAEGMGYLESK---------------------------------------------RFIHRDL-----AARNLLLAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLVKIGDFGLMRALPQNDDH--YVMQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRKVPFAWCAPESLKT--------------------------------RTFS-HASDTWMFGVTLWEMFTY--G--------------QEPWIG--------------------------------------------------LNGSQILHKIDKE--GERLPRPEDCP----------------------------------------------------------------------------------------------------QDIYNVMVQCWAHKPEDRPT--------------FVALRDFLLE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRLL----------------EKLGDGS----------------FGVVRRGEW--DAPSG---------------------------------KTVSVAVKCLK--PDVLSQPEA-------------------------MDDFIREVNAMHSL--------------------------DHRNLIRLYGVVLTP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMKMVTELAPL--------------GSLLDRLRK--HQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFLLGTLSRYAVQVAEGMGYLESK---------------------------------------------RFIHRDL-----AARNLLLAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLVKIGDFGLMRALP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPFAWCAPESLKT--------------------------------RTFS-HASDTWMFGVTLWEMFTY--G--------------QEPWIG--------------------------------------------------LNGSQILHKIDKE--GERLPRPEDCP----------------------------------------------------------------------------------------------------QDIYNVMVQCWAHKPEDRPT--------------FVALRDFLLE
Activation segment
DFGLMRALP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPFAWCAPE
Binding pocket
EKLGDGSFGVVRRVAVKCLDFIREVNAMHSLDRNLIRLYGVKMVTELAPLGSLLDRLRKYLESKRFIHRDLAARNLLLIGDFGLM
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4HZS, Chain D