4GT4 Chain A
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Inactive — 1.3%DFG-outαC-out
Resolution
2.41 Å
R-value
0.179
Predicted activity confidence1.3%
Structure info
Alternate conformationB
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KLKEISLSAVRFMEELGEDRFGKVYKGHLFTQAVAIKTLKDAEGLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGN
UniProt reference sequence
VRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRA
Aligned reference sequence
VRFM----------------EELGEDR----------------FGKVYKGHL--FGPAPGE-------------------------------QTQAVAIKTLK--DKAEGPL---------------------------REEFRHEAMLRARL--------------------------QHPNVVCLLGVVTKDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSMIFSYCSH--------------GDLHEFLVM--RSPHSDVGSTDDDRTVKS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALEPPDFVHLVAQIAAGMEYLSSH---------------------------------------------HVVHKDL-----ATRNVLVYD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLNVKISDLGLFREVYAADYY--KLL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNSLLPIRWMAPEAIMY--------------------------------GKFS-IDSDIWSYGVVLWEVFSY--G--------------LQPYCG--------------------------------------------------YSNQDVVEMIRNR--QVLPCPDDCP-----------------------------------------------------------------------------------------------------AWVYALMIECWNEFPSRRPR--------------FKDIHSRLRA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VRFM----------------EELGEDR----------------FGKVYKGHL--F--------------------------------------TQAVAIKTLK--D-AEG-L---------------------------REEFRHEAMLRARL--------------------------QHPNVVCLLGVVTKDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSMIFSYCSH--------------GDLHEFLVM--RSPHSDVG-----RTVKS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALEPPDFVHLVAQIAAGMEYLSSH---------------------------------------------HVVHKDL-----ATRNVLVYD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLNVKISDLGLFREVYAADYY--KLL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNSLLPIRWMAPEAIMY--------------------------------GKFS-IDSDIWSYGVVLWEVFSY--G--------------LQPYCG--------------------------------------------------YSNQDVVEMIRNR--QVLPCPDDCP-----------------------------------------------------------------------------------------------------AWVYALMIECWNEFPSRRPR--------------FKDIHSRLRA
Activation segment
DLGLFREVYAADYY--KLL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNSLLPIRWMAPE
Binding pocket
EELGEDRFGKVYKVAIKTLEFRHEAMLRARLQPNVVCLLGVSMIFSYCSHGDLHEFLVMYLSSHHVVHKDLATRNVLVISDLGLF
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4GT4, Chain A