4GK4 Chain A
Ephrin type-A receptor 3 (EPHA3)
Active — 50.2%DFG-inαC-inType1.5_Back · L90
Resolution
2.1 Å
R-value
0.176
Predicted activity confidence50.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITNLLL
UniProt reference sequence
ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK
Aligned reference sequence
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Activation segment
DFGLSRVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTSPE
Binding pocket
KVVGAGEFGEVCSVAIKTLDFLGEASIMGQFDPNIIRLEGVMIVTEYMENGSLDSFLRKYLSDMGYVHRDLAARNILIVSDFGLS
Ligand info
Orthosteric ligand
L90
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4GK4, Chain A