4GK2 Chain A
Ephrin type-A receptor 3 (EPHA3)
Inactive — 0.2%DFG-inαC-inType1.5_Back · L66
Resolution
2.19 Å
R-value
0.193
Predicted activity confidence0.2%
Structure info
Alternate conformationB
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRLKIITNLLL
UniProt reference sequence
ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK
Aligned reference sequence
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Activation segment
DFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTSPE
Binding pocket
KVVGAGEFGEVCSVAIKTLDFLGEASIMGQFDPNIIRLEGVMIVTEYMENGSLDSFLRKYLSDMGYVHRDLAARNILIVSDFGL_
Ligand info
Orthosteric ligand
L66
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4GK2, Chain A