4GFO Chain A
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Inactive — 0.1%DFG-inαC-inType1 · 0X2
Resolution
2.3 Å
R-value
0.237
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALWKQEIDILRTLYHEHIIKYKGCCELQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYRH
UniProt reference sequence
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTR
Aligned reference sequence
ITQL----------------SHLGQGT----------------RTNVYEGRL--RVEGSGDPEEGKMDDEDPLVPGRDRG------------QELRVVLKVLD--PSHHDI----------------------------ALAFYETASLMSQV--------------------------SHTHLAFVHGVCVRGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVTEYVEH--------------GPLDVWLRR--ERG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVPMAWKMVVAQQLASALSYLENK---------------------------------------------NLVHGNV-----CGRNILLAR--LGLAEGT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPFIKLSDPGVGLGALSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVERIPWLAPECLPG--GA----------------------------NSLS-TAMDKWGFGATLLEICFD--G--------------EAPLQS--------------------------------------------------RSPSEKEHFYQRQ--HRLPEPSC-------------------------------------------------------------------------------------------------------PQLATLTSQCLTYEPTQRPS--------------FRTILRDLTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
-------------------------TV----------------FHKRYLKKI--RDLGEGHFGKVSLYCYDP----TNDG------------TGEMVAVKALW--KQEIDI----------------------------LRTLY------------------------------------HEHIIKYKGCC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELQLVMEYVPL--------------GSLRDYL----PRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHSQ---------------------------------------------HYIHRNL-----AARNVLLDN--DRLVKIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFGLAKAVPEGHEYYRVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGDSPVFWYAPECL----KE----------------------------YKFY-YASDVWSFGVTLYE---L--L--------------THCDSS--------------------------------------------------QSPPTKTELLERG--ERLPRPDC-------------------------------------------------------------------------------------------------------PCEVYLMKNCWETEASFRPT--------------FKTVHEKYRH
Activation segment
VPEGHEYYRVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGDSPVFWYAPE
Binding pocket
RDLGEGHFGKVSLVAVKAL_WKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHSQHYIHRNLAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
0X2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4GFO, Chain A