4GEO Chain A
Mitogen-activated protein kinase 14 (MAPK14)
Inactive — 0.0%DFG-outαC-in
Resolution
1.66 Å
R-value
0.22
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues8
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RPTFYRQELNKTIWEVPERYQNLSPVGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLATRWYRAPEIAANWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDAADQLKLILRLVGTPGAELLKKISSESARNAIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP
UniProt reference sequence
YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
Aligned reference sequence
YQNL----------------SPVGSGA----------------YGSVCAAFD--TK------------------------------------TGLRVAVKKLS--RPFQSIIH--------------------------AKRTYRELRLLKHM--------------------------KHENVIGLLDVFTPAR--SLEEFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVTHLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA---------------------------------------------DIIHRDL-----KPSNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARHTDDEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLTG-----------------RTLFPG--------------------------------------------------TDHIDQLKLILRL--VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----------------------------------------------------------------------PLAVDLLEKMLVLDSDKRIT--------------AAQALAHAYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQNL----------------SPV---------------------GSVCAAFD--TK------------------------------------TGLRVAVKKLS--RPFQSIIH--------------------------AKRTYRELRLLKHM--------------------------KHENVIGLLDVFTPAR--SLEEFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVTHLMG---------------ADLNNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA---------------------------------------------DIIHRDL-----KPSNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATRWYRAPEIAAN--W-----------------------------MHYN-QTVDIWSVGCIMAELLTG-----------------RTLFPG--------------------------------------------------TDAADQLKLILRL--VGTPGAELLKKISSESARNAIQSLTQMPKMNFANVFIGAN-----------------------------------------------------------------------PLAVDLLEKMLVLDSDKRIT--------------AAQALAHAYF
Activation segment
DFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATRWYRAPE
Binding pocket
SPVG_____SVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNI___YIHSADIIHRDLKPSNLAVILDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4GEO, Chain A