4G3G Chain A
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
Active — 96.6%DFG-inαC-inType1 · 0WA
Resolution
2.5 Å
R-value
0.201
Predicted activity confidence96.6%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SGSVSSGQAHSLASLAKTWSGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRLGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRG
UniProt reference sequence
WATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR
Aligned reference sequence
WATH--Q-------------LRLGRGS----------------FGEVHRMED--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRAEELMACAGL--------------------------TSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLVKE--QG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHSR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSHAALCDFGHAVCLQPDGLG--KSLLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVLG--------------------------------RSCD-AKVDVWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------FFRGPLCLKIASE--PPPVREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPIHRVS--------------AAELGGKVNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WMTH--Q-------------PRLGRGS----------------FGEVHRMKD--KQ------------------------------------TGFQCAVKKVR--L---------------------------------EVFRVEELVACAGL--------------------------SSPRIVPLYGAVREGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WVNIFMELLEG--------------GSLGQLIKQ--MG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLPEDRALYYLGQALEGLEYLHTR---------------------------------------------RILHGDV-----KADNVLLSS--D-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSRAALCDFGHALCL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPEVVMG--------------------------------KPCD-AKVDIWSSCCMMLHMLNG-----------------CHPWTQ--------------------------------------------------YFRGPLCLKIASE--PPPIREIPPSCA---------------------------------------------------------------------------------------------------PLTAQAIQEGLRKEPVHRAS--------------AMELRRKVRG
Activation segment
DFGHALCL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYIPGTETHMAPE
Binding pocket
PRLGRGSFGEVHRCAVKKVFRVEELVACAGLSPRIVPLYGANIFMELLEGGSLGQLIKQYLHTRRILHGDVKADNVLLLCDFGHA
Ligand info
Orthosteric ligand
0WA
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4G3G, Chain A