4G34 Chain A
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Inactive — 0.0%DFG-inαC-outType1.5_Back · 924
Resolution
2.7 Å
R-value
0.21
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms15
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEKNKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFED
UniProt reference sequence
FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
Aligned reference sequence
FEPI----------------QCLGRGG----------------FGVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLEAP--PEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV--YLYIQMQLCRK--------------ENLKDWMNG--RCTIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERERSVCLHIFLQIAEAVEFLHSK---------------------------------------------GLMHRDL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDFGLVTAMDQDEEE--QTVLTPMPAYARH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGQVGTKLYMSPEQIHG--------------------------------NSYS-HKVDIFSLGLILFELLYP-------------------------FSTQ--------------------------------------------MERVRTLTDVRNL--KFPPLFTQKY-----------------------------------------------------------------------------------------------------PCEYVMVQDMLSPSPMERPE--------------AINIIENAVF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEPI----------------QCLGRGG----------------FGVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KN----------KV--YLYIQMQLCRK--------------ENLKDWMNG--RCTIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERERSVCLHIFLQIAEAVEFLHSK---------------------------------------------GLMHRDL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKLYMSPEQIHG--------------------------------NSYS-HKVDIFSLGLILFELLYP-------------------------FSTQ--------------------------------------------MERVRTLTDVRNL--KFPPLFTQKY-----------------------------------------------------------------------------------------------------PCEYVMVQDMLSPSPMERPE--------------AINIIENAVF
Activation segment
DFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKLYMSPE
Binding pocket
QCLGRGGFGVVFEYAIKRIKVMREVKALAKLEPGIVRYFNAYIQMQLCRKENLKDWMNGFLHSKGLMHRDLKPSNIFFVGDFGL_
Ligand info
Orthosteric ligand
924
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4G34, Chain A