4FZD Chain B
Serine/threonine-protein kinase 26 (STK26)
Inactive — 1.4%DFG-outαC-out
Resolution
3.25 Å
R-value
0.222
Predicted activity confidence1.4%
Structure info
Alternate conformation—
Missing atoms13
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAE
UniProt reference sequence
FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLAAFGVAGQLT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Activation segment
AFGVAGQLT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPE
Binding pocket
ERIGKGSFGEVFKVAIKIIDIQQEITVLSQCDSYVTKYYGSWIIMEYLGGGSALDLLRAYLHSEKKIHRDIKAANVLLLAAFGVA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FZD, Chain B