4FGB Chain A
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Inactive — 0.0%DFG-inαC-out
Resolution
2.6 Å
R-value
0.251
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFA
UniProt reference sequence
YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
Aligned reference sequence
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--KEALEGK---------------------------EGSMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--K-----------------------------------SMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Activation segment
DFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPE
Binding pocket
DVLGTGAFSEVILVAIKCISMENEIAVLHKIKPNIVALDDIYLIMQLVSGGELFDRIVEYLHDLGIVHRDLKPENLLYISDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FGB, Chain A