4FG8 Chain B
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Inactive — 4.2%DFG-inαC-outATPlike · ATP
Resolution
2.2 Å
R-value
0.198
Predicted activity confidence4.2%
Structure info
Alternate conformation—
Missing atoms33
Missing residues5
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
EDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKNEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFA
UniProt reference sequence
YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
Aligned reference sequence
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--KEALEGK---------------------------EGSMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--K--------------------------------------NEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFG-------GSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Activation segment
DFG-------GSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPE
Binding pocket
DVLGTGAFSEVILVAIKCI___NEIAVLHKIKPNIVALDDIYLIMQLVSGGELFDRIVEYLHDLGIVHRDLKPENLLYISDFG__
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FG8, Chain B