4FG8 Chain A
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Inactive — 0.4%DFG-outαC-outATPlike · ATP
Resolution
2.2 Å
R-value
0.198
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms31
Missing residues5
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFA
UniProt reference sequence
YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
Aligned reference sequence
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--KEALEGK---------------------------EGSMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--K-------------------------------------ENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Activation segment
DF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPGYVAPE
Binding pocket
DVLGTGAFSEVILVAIKCI__ENEIAVLHKIKPNIVALDDIYLIMQLVSGGELFDRIVEYLHDLGIVHRDLKPENLLYISDF___
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FG8, Chain A