4FG7 Chain A
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Active — 91.2%DFG-inαC-inATPlike · ATP
Resolution
2.7 Å
R-value
0.221
Predicted activity confidence91.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIASMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGTPGYVAPEVLAQKSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA
UniProt reference sequence
YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
Aligned reference sequence
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--KEALEGK---------------------------EGSMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDPGSVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDFR----------------DVLGTGA----------------FSEVILAED--KR------------------------------------TQKLVAIKCIA--------------------------------------SMENEIAVLHKI--------------------------KHPNIVALDDIYESGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLIMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTERDASRLIFQVLDAVKYLHDL---------------------------------------------GIVHRDL-----KPENLLYYS--LDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSKIMISDFGLSKMEDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPGYVAPEVLAQ--------------------------------K--S-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDAKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRHLMEKDPEKRFT--------------CEQALQHPWI
Activation segment
DFGLSKMEDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPGYVAPE
Binding pocket
DVLGTGAFSEVILVAIKCISMENEIAVLHKIKPNIVALDDIYLIMQLVSGGELFDRIVEYLHDLGIVHRDLKPENLLYISDFGLS
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FG7, Chain A