4FF8 Chain A
Tyrosine-protein kinase receptor TYRO3 (TYRO3)
Inactive — 0.1%DFG-outαC-outType1 · 14S
Resolution
2.4 Å
R-value
0.279
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues37
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KEFDHPHVAKLVILPFMKHGDLHAFLLASRIPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVAVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMVYDLMYQCWSADPKQRPSFTCLRMELENIL
UniProt reference sequence
FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELEN
Aligned reference sequence
FTLG----------------RMLGKGE----------------FGSVREAQL--KQEDG---------------------------------SFVKVAVKMLK--ADIIASSD--------------------------IEEFLREAACMKEF--------------------------DHPHVAKLVGVSLRSR--AKGRLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPMVILPFMKH--------------GDLHAFLLA--SRIGENPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPLQTLIRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSRKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CASKLPVKWLALESLAD--------------------------------NLYT-VQSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-----------------------------------------------------------------------------------------------------EDVYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
------------------------------------------------------------------------------------------------------------------------------------------------------KEF--------------------------DHPHVAKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VILPFMKH--------------GDLHAFLLA--SRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQTLVRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKWLALESLAD--------------------------------NLYT-VHSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-------------------------------------------------------------------------------------------------------VYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Activation segment
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKWLALE
Binding pocket
____________________________KEFDPHVAKL____VILPFMKHGDLHAFLLAYLSSRNFIHRDLAARNCMLVA_____
Ligand info
Orthosteric ligand
14S
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FF8, Chain A