4FEQ Chain A
Tyrosine-protein kinase receptor TYRO3 (TYRO3)
Inactive — 1.3%DFG-inαC-outType1 · 0T8
Resolution
2.2 Å
R-value
0.278
Predicted activity confidence1.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EQQFTLGRMLGKGSVREAQLKDGSFVKVAVKMLFLREAACMKEFDHPHVAKLVGVSPMVILPFMKHGDLHAFLLASRIPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHL
UniProt reference sequence
FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELEN
Aligned reference sequence
FTLG----------------RMLGKGE----------------FGSVREAQL--KQEDG---------------------------------SFVKVAVKMLK--ADIIASSD--------------------------IEEFLREAACMKEF--------------------------DHPHVAKLVGVSLRSR--AKGRLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPMVILPFMKH--------------GDLHAFLLA--SRIGENPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPLQTLIRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSRKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CASKLPVKWLALESLAD--------------------------------NLYT-VQSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-----------------------------------------------------------------------------------------------------EDVYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTLG----------------RMLGK-------------------GSVREAQL--K--DG---------------------------------SFVKVAVKML----------------------------------------FLREAACMKEF--------------------------DHPHVAKLVGVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMVILPFMKH--------------GDLHAFLLA--SRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLQTLVRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKWLALESLAD--------------------------------NLYT-VHSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-----------------------------------------------------------------------------------------------------EEVYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Activation segment
DFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKWLALE
Binding pocket
RMLGKG___SVREVAVKML_FLREAACMKEFDPHVAKLVGVMVILPFMKHGDLHAFLLAYLSSRNFIHRDLAARNCMLVADFG__
Ligand info
Orthosteric ligand
0T8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4FEQ, Chain A