4F9B Chain C
Cell division cycle 7-related protein kinase (CDC7)
Inactive — 26.0%DFG-outαC-inType1 · 0SY
Resolution
2.5 Å
R-value
0.19
Predicted activity confidence26.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM
UniProt reference sequence
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF
Aligned reference sequence
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFVQSEAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLR-------------------------------------------------------------------GWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Activation segment
DFGLAQGTHDTKIE--LLKFVQSEAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAGTPGFRAPE
Binding pocket
DKIGEGTFSSVYLIALKHLRIAAELQCLTVAGDNVMGVKYCVIAMPYLE_HESFLD__IRIHQFGIVHRDVKPSNFLYLVDFGLA
Ligand info
Orthosteric ligand
0SY
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4F9B, Chain C