4F6W Chain A
Cyclin-dependent kinase 8 (CDK8)
Inactive — 0.0%DFG-outαC-inType2 · 0SS
Resolution
2.39 Å
R-value
0.193
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFATFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFL
UniProt reference sequence
FEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF
Aligned reference sequence
FEYE--G-------------CKVGRGT----------------YGHVYKAKR--KDGK----------------------------------DDKDYALKQIE--GTGI------------------------------SMSACREIALLREL--------------------------KHPNVISLQKVFLSHA--DR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVWLLFDYAE---------------HDLWHIIKF--HRASKANKKPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLPRGMVKSLLYQILDGIHYLHAN---------------------------------------------WVLHRDL-----KPANILVMG--EGPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRVKIADMGFARLFNSPLKP--LADL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPVVVTFWYRAPELLLG--A-----------------------------RHYT-KAIDIWAIGCIFAELLTS-----------------EPIFHC--RQEDIKTSN---------------------------------------PYHHDQLDRIFNV--MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPD----------------------------------------------------------------SKAFHLLQKLLTMDPIKRIT--------------SEQAMQDPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEYE--G-------------CKVGRGT----------------YGHVYKAKR--KDGK----------------------------------DDKDYALKQIE--GTGI------------------------------SMSACREIALLREL--------------------------KHPNVISLQKVFLSHA--DR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVWLLFDYAE---------------HDLWHIIKF--HRASK-----V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLPRGMVKSLLYQILDGIHYLHAN---------------------------------------------WVLHRDL-----KPANILVMG--EGPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRVKIADMGFA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFWYRAPELLLG--A-----------------------------RHYT-KAIDIWAIGCIFAELLTS-----------------EPIFHC--RQ------N---------------------------------------PYHHDQLDRIFNV--MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPD----------------------------------------------------------------SKAFHLLQKLLTMDPIKRIT--------------SEQAMQDPYF
Activation segment
DMGFA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFWYRAPE
Binding pocket
CKVGRGTYGHVYKYALKQISACREIALLRELKPNVISLQKVWLLFDYAE_HDLWHIIKFYLHANWVLHRDLKPANILVIADMGFA
Ligand info
Orthosteric ligand
0SS
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4F6W, Chain A