4EYM Chain A
Mitogen-activated protein kinase 13 (MAPK13)
Inactive — 0.0%DFG-inαC-inType1 · 0RX
Resolution
2.35 Å
R-value
0.206
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP
UniProt reference sequence
YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
Aligned reference sequence
YVSP----------------THVGSGA----------------YGSVCSAID--KR------------------------------------SGEKVAIKKLS--RPFQSEIF--------------------------AKRAYRELLLLKHM--------------------------QHENVIGLLDVFTPAS--SLRNFY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMQ---------------TDLQKIMGM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSEEKIQYLVYQMLKGLKYIHSA---------------------------------------------GVVHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARHADAEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILS--W-----------------------------MHYN-QTVDIWSVGCIMAEMLTG-----------------KTLFKG--------------------------------------------------KDYLDQLTQILKV--TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS-----------------------------------------------------------------------PQAADLLEKMLELDVDKRLT--------------AAQALTHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVSP----------------THVGSGA----------------YGSVCSAID--KR------------------------------------SGEKVAIKKLS--RPFQSEIF--------------------------AKRAYRELLLLKHM--------------------------QHENVIGLLDVFTPAS--SLRNFY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMQ---------------TDLQKIMGM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSEEKIQYLVYQMLKGLKYIHSA---------------------------------------------GVVHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVVTRWYRAPEVILS--W-----------------------------MHYN-QTVDIWSVGCIMAEMLTG-----------------KTLFKG--------------------------------------------------KDYLDQLTQILKV--TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS-----------------------------------------------------------------------PQAADLLEKMLELDVDKRLT--------------AAQALTHPFF
Activation segment
DFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVVTRWYRAPE
Binding pocket
THVGSGAYGSVCSVAIKKLRAYRELLLLKHMQENVIGLLDVYLVMPFMQ_TDLQKIMGMYIHSAGVVHRDLKPGNLAVILDFGL_
Ligand info
Orthosteric ligand
0RX
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4EYM, Chain A