4EQU Chain B
Serine/threonine-protein kinase 10 (STK10)
Inactive — 1.4%DFG-outαC-inType2 · G6I
Resolution
2.0 Å
R-value
0.224
Predicted activity confidence1.4%
Structure info
Alternate conformationB
Missing atoms13
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE
UniProt reference sequence
WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
Aligned reference sequence
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVIE--TKSEEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNLKTLQK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETMKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVI------EEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPEVVMC--ETMKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Activation segment
DFGVSAKNL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPE
Binding pocket
GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS
Ligand info
Orthosteric ligand
G6I
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4EQU, Chain B