4E93 Chain A
Tyrosine-protein kinase Fes/Fps (FES)
Inactive — 0.5%DFG-inαC-inType1 · GUI
Resolution
1.84 Å
R-value
0.189
Predicted activity confidence0.5%
Structure info
Alternate conformationB
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
UniProt reference sequence
LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQS
Aligned reference sequence
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Activation segment
DFGMSRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPVKWTAPE
Binding pocket
EQIGRGNFGEVFSVAVKSCKFLQEARILKQYSPNIVRLIGVYIVMELVQGGDFLTFLRTYLESKCCIHRDLAARNCLVISDFGMS
Ligand info
Orthosteric ligand
GUI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4E93, Chain A