4E1Z Chain A
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Inactive — 34.4%DFG-inαC-inType1 · 0MX
Resolution
2.5 Å
R-value
0.199
Predicted activity confidence34.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQ
UniProt reference sequence
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTR
Aligned reference sequence
ITQL----------------SHLGQGT----------------RTNVYEGRL--RVEGSGDPEEGKMDDEDPLVPGRDRG------------QELRVVLKVLD--PSHHDI----------------------------ALAFYETASLMSQV--------------------------SHTHLAFVHGVCVRGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVTEYVEH--------------GPLDVWLRR--ERG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVPMAWKMVVAQQLASALSYLENK---------------------------------------------NLVHGNV-----CGRNILLAR--LGLAEGT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPFIKLSDPGVGLGALSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVERIPWLAPECLPG--GA----------------------------NSLS-TAMDKWGFGATLLEICFD--G--------------EAPLQS--------------------------------------------------RSPSEKEHFYQRQ--HRLPEPSC-------------------------------------------------------------------------------------------------------PQLATLTSQCLTYEPTQRPS--------------FRTILRDLTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKKI----------------RDLGEGH----------------FGKVYCYDP--TNDGTGEMVAVKALKEGCGPQLRSGW------------QREIEILRTLY--HEHIVK----------------------------YKGCCEDKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQLVMEYVPL--------------GSLRDYL----PRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVGLAQLLLFAQQICEGMAYLHAQ---------------------------------------------HYIHRAL-----AARNVLLDN--DRLVKIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFGLAKAVPEGHEYYRVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGDSPVFWYAPECL----KE----------------------------CKFY-YASDVWSFGVTLYE---L--L--------------TYCDSN--------------------------------------------------QSPHTKTELLERG--ERLPRPDC-------------------------------------------------------------------------------------------------------PCEIYLMKNCWETEASFRPT--------------FQNLVPILYQ
Activation segment
VPEGHEYYRVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGDSPVFWYAPE
Binding pocket
RDLGEGHFGKVSLVAVKALGWQREIEILRTLYEHIVKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRALAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
0MX
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4E1Z, Chain A