4DC2 Chain A
Protein kinase C iota type (PRKCI)
Active — 100.0%DFG-inαC-inType1 · ADE
Resolution
2.4 Å
R-value
0.176
Predicted activity confidence100.0%
Structure info
Alternate conformationA
Missing atoms14
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMRVVKKELVNIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLPDDDDIVRKIDQSEFEGFEYINP
UniProt reference sequence
FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
Aligned reference sequence
FDLL----------------RVIGRGS----------------YAKVLLVRL--KK------------------------------------TDRIYAMKVVK--KELVNDDED-------------------------IDWVQTEKHVFEQA--S-----------------------NHPFLVGLHSCFQTES--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVIEYVNG--------------GDLMFHMQR--QR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPEEHARFYSAEISLALNYLHER---------------------------------------------GIIYRDL-----KLDNVLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPNYIAPEILRG--------------------------------EDYG-FSVDWWALGVLMFEMMAG-----------------RSPFDI--VGSSDNPDQ---------------------------------------NTEDYLFQVILEK--QIRIPRSLS------------------------------------------------------------------------------------------------------VKAASVLKSFLNKDPKERLG--CHPQTG------FADIQGHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDLL----------------RVIGRGS----------------YAKVLLVRL--KK------------------------------------TDRIYAMRVVK--KELVN-----------------------------IDWVQTEKHVFEQA--S-----------------------NHPFLVGLHSCFQTES--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVIEYVNG--------------GDLMFHMQR--QR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPEEHARFYSAEISLALNYLHER---------------------------------------------GIIYRDL-----KLDNVLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPNYIAPEILRG--------------------------------EDYG-FSVDWWALGVLMFEMMAG-----------------RSPFDI--VGS---------------------------------------------NTEDYLFQVILEK--QIRIPRSLS------------------------------------------------------------------------------------------------------VKAASVLKSFLNKDPKERLG--CHPQTG------FADIQGHPFF
Activation segment
DYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPNYIAPE
Binding pocket
RVIGRGSYAKVLLYAMRVVWVQTEKHVFEQASPFLVGLHSCFFVIEYVNGGDLMFHMQRYLHERGIIYRDLKLDNVLLLTDYGMC
Ligand info
Orthosteric ligand
ADE
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4DC2, Chain A