4D2T Chain A
Maternal embryonic leucine zipper kinase (MELK)
Inactive — 8.2%DFG-inαC-inType1 · 3I7
Resolution
2.7 Å
R-value
0.273
Predicted activity confidence8.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCACCGALAYAAPELIQGKSGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR
UniProt reference sequence
YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
Aligned reference sequence
YELH----------------ETIGTGG----------------FAKVKLACH--IL------------------------------------TGEMVAIKIMD--KNTLGSD---------------------------LPRIKTEIEALKNL--------------------------RHQHICQLYHVLETAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIFMVLEYCPG--------------GELFDYIIS--QD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQ---------------------------------------------GYAHRDL-----KPENLLFDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHKLKLIDFGLCAKPKGNKDY--HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTCCGSLAYAAPELIQG--------------------------------KSYLGSEADVWSMGILLYVLMCG-----------------FLPFDD--------------------------------------------------DNVMALYKKIMRG--KYDVPKWLS------------------------------------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS--------------MKNLLNHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YELH----------------ETIGTGG----------------FAKVKLACH--IL------------------------------------TGEMVAIKIMD--KNT---D---------------------------LPRIKTEIEALKNL--------------------------RHQHICQLYHVLETAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIFMVLEYCPG--------------GELFDYIIS--QD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQ---------------------------------------------GYAHRDL-----KPENLLFDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHKLKLIDFGLCA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CCGALAYAAPELIQG--------------------------------KS--GSEADVWSMGILLYVLMCG-----------------FLPFDD--------------------------------------------------DTAAALVAKIMRG--KYDVPKWLS------------------------------------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS--------------MKNLLNHPWI
Activation segment
DFGLCA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CCGALAYAAPE
Binding pocket
ETIGTGGFAKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLEYCPGGELFDYIISYVHSQGYAHRDLKPENLLFLIDFGLC
Ligand info
Orthosteric ligand
3I7
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4D2T, Chain A