4D1Z Chain A
Cyclin-dependent kinase 2 (CDK2)
Inactive — 0.0%DFG-inαC-outType1,Allosteric · WG8
Resolution
1.85 Å
R-value
0.195
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms38
Missing residues7
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
NFQKVEKIGGVVYKARNKLTGEVVALKKIAIREISLLKELNHPNIVKLLDVIHTKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH
UniProt reference sequence
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Aligned reference sequence
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--LDTETEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPVRT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQKV----------------EKIG--------------------GVVYKARN--KL------------------------------------TGEVVALKKI----------------------------------------AIREISLLKEL--------------------------NHPNIVKLLDVIHT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPE
Binding pocket
EKIG____GVVYKVALKKI_AIREISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFG__
Ligand info
Orthosteric ligand
WG8
Allosteric ligand
WG8
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4D1Z, Chain A