4CRS Chain A
Serine/threonine-protein kinase N2 (PKN2)
Active — 99.6%DFG-inαC-inATPlike · AGS
Resolution
2.75 Å
R-value
0.213
Predicted activity confidence99.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILPPREPREMFRDFDYIADWC
UniProt reference sequence
FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
Aligned reference sequence
FRCC----------------AVLGRGH----------------FGKVLLAEY--KN------------------------------------TNEMFAIKALK--KGDIVARDE-------------------------VDSLMCEKRIFETV--NSV---------------------RHPFLVNLFACFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYAAG--------------GDLMMHIHT--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGFVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPEFLAPEVLTE--------------------------------TSYT-RAVDWWGLGVLIYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------TEAISIMRRLLRRNPERRLG--ASEKD-------AEDVKKHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRCC----------------AVLLRGH----------------FGKVLLAEY--KN------------------------------------TNEMFAIKALK--KGDIVARDE-------------------------VDSLMCEKRIFETV--NSV---------------------RHPFLVNLFACFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYAAG--------------GDLMMHIHT--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VF-EPRAVFYAACVVLGLQYLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGFVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPEVLTE--------------------------------TSYT-RAVDWWGLGVLIYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------TEAISIMRRLLRRNPERRLG--ASEKD-------AEDVKKHPFF
Activation segment
DFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPE
Binding pocket
AVLLRGHFGKVLLFAIKALSLMCEKRIFETVNPFLVNLFACCFVMEYAAGGDLMMHIHTYLHEHKIVYRDLKLDNLLLIADFGLC
Ligand info
Orthosteric ligand
AGS
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4CRS, Chain A