4CNH Chain A
ALK tyrosine kinase receptor (ALK)
Inactive — 6.2%DFG-inαC-inType1 · 3U9
Resolution
1.9 Å
R-value
0.206
Predicted activity confidence6.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PNYCFAGKTSSISDLKEVPRKNITLIRGLEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYG
UniProt reference sequence
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
Aligned reference sequence
ITLI----------------RGLGHGA----------------FGEVYEGQV--SGMPNDP-------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRASYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLI----------------RGL----------------------EVYEGQV----------------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Activation segment
DFGMARDIYR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPVKWMPPE
Binding pocket
RGL______EVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Ligand info
Orthosteric ligand
3U9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4CNH, Chain A