4CFE Chain A
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Active — 100.0%DFG-inαC-outType1,Allosteric · STU
Resolution
3.02 Å
R-value
0.219
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA
UniProt reference sequence
YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
Aligned reference sequence
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Activation segment
DFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPE
Binding pocket
DTLGVGTFGKVKIVAVKILKIKREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLLIADFGLS
Ligand info
Orthosteric ligand
STU
Allosteric ligand
992
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4CFE, Chain A