4C57 Chain A
Cyclin-G-associated kinase (GAK)
Active — 97.3%DFG-inαC-inType1 · FEF
Resolution
2.55 Å
R-value
0.18
Predicted activity confidence97.3%
Structure info
Alternate conformationA
Missing atoms9
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQ
UniProt reference sequence
LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQE
Aligned reference sequence
LRVR----------------RVLAEGG----------------FAFVYEAQD--VG------------------------------------SGREYALKRLL--SNEEEK----------------------------NRAIIQEVCFMKKL--S-----------------------GHPNIVQFCSAASIGK--EESDTGQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFLLLTELCK---------------GQLVEFLKK--MESRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSCDTVLKIFYQTCRAVQHMHRQ--KP-----------------------------------------PIIHRDL-----KVENLLLSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGTIKLCDFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPEIIDL--YSN---------------------------FPIG-EKQDIWALGCILYLLCFR-----------------QHPFED------------------------------------------------------GAKLRIVNG--KYSIPPHDTQY----------------------------------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS--------------IAEVVHQLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRVR----------------RVLAEGG----------------FAFVYEAQD--VG------------------------------------SGREYALKRLL--SNEEEK----------------------------NRAIIQEVCFMKKL--S-----------------------GHPNIVQFCSAASIGK--EESDTGQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFLLLTELCK---------------GQLVEFLKK--MESRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSCDTVLKIFYQTCRAVQHMHRQ--KP-----------------------------------------PIIHRDL-----KVENLLLSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGTIKLCDFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPEIIDL--YSN---------------------------FPIG-EKQDIWALGCILYLLCFR-----------------QHPFED------------------------------------------------------GAKLRIVNG--KYSIPPHDTQY----------------------------------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS--------------IAEVVHQLQE
Activation segment
DFGSATTISHYPDY--SWSAQRRALVEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITRNTTPMYRTPE
Binding pocket
RVLAEGGFAFVYEYALKRLAIIQEVCFMKKLSPNIVQFCSALLLTELCK_GQLVEFLKKHRQKPPIIHRDLKVENLLLLCDFGSA
Ligand info
Orthosteric ligand
FEF
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4C57, Chain A