4BTM Chain A
Tau-tubulin kinase 1 (TTBK1)
Active — 99.9%DFG-inαC-inType1 · F8E
Resolution
2.54 Å
R-value
0.179
Predicted activity confidence99.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEK
UniProt reference sequence
WKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFEN
Aligned reference sequence
WKVL----------------KKIGGGG----------------FGEIYEAMD--LL------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QPRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLSTTLRLGKQILESIEAIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--LPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRKCYMLDFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVNAHKN--------------------------------REMG-RHDDLWSLFYMLVEFAVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGMIKEKY--EHRMLLKHMP-----------------------------------------------------------------------------------------------------SEFHLFLDHIASLDYFTKPD--------------YQLIMSVFEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WKVL----------------KKIGGGG----------------FGEIYEAMD--LL------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QPRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLSTTLRLGKQILESIEAIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--LPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRKCYMLDFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVNAHKN--------------------------------REMG-RHDDLWSLFYMLVEFAVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGMIKEKY--EHRMLLKHMP-----------------------------------------------------------------------------------------------------SEFHLFLDHIASLDYFTKPD--------------YQLIMSVFEN
Activation segment
DFGLARQYTNTTGD--VRPPRNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASVN
Binding pocket
KKIGGGGFGEIYEVALKVEVLKMEVAVLKKLQDHVCRFIGCYVVMQLQG_RNLADLRRSAIHSVGFLHRDIKPSNFAMMLDFGLA
Ligand info
Orthosteric ligand
F8E
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4BTM, Chain A