4BI0 Chain A
Dual specificity protein kinase TTK (TTK)
Inactive — 0.0%DFG-inαC-inType1 · Z0W
Resolution
2.84 Å
R-value
0.186
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQQVGTVNYMPPEAIKDISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ
UniProt reference sequence
YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV
Aligned reference sequence
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQMQPDTTS--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSQVGTVNYMPPEAIKD--MSSSRENGKSK-------------------SKIS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVGTVNYMPPEAIKD----------------------------------IS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Activation segment
DFGIANQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVGTVNYMPPE
Binding pocket
KQIGSGGSSKVFQYAIKYVSYRNEIAYLNKLQDKIIRLYDYYMVMECGN_IDLNSWLKKTIHQHGIVHSDLKPANFLILIDFGIA
Ligand info
Orthosteric ligand
Z0W
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4BI0, Chain A