4BGG Chain C
Activin receptor type-1 (ACVR1)
Active — 98.4%DFG-inαC-inType1 · 844
Resolution
2.56 Å
R-value
0.217
Predicted activity confidence98.4%
Structure info
Alternate conformationA
Missing atoms26
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAREDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
UniProt reference sequence
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
Aligned reference sequence
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--I----GKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTN-----VGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVAR----------EDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Activation segment
DLGLAVMHSQSTN-----VGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETELYNTVMENILGFIASWLITHYHEMGSLYDYLQL__GKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
844
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4BGG, Chain C