4BCG Chain A
Cyclin-dependent kinase 9 (CDK9)
Active — 99.8%DFG-inαC-inType1 · T3C
Resolution
3.08 Å
R-value
0.163
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGM
UniProt reference sequence
YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
Aligned reference sequence
YEKL----------------AKIGQGT----------------FGEVFKARH--RK------------------------------------TGQKVALKKVL--MENEKEGF--------------------------PITALREIKILQLL--------------------------KHENVVNLIEICRTKA--SPYNRCKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIYLVFDFCE---------------HDLAGLLSN--VLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRN---------------------------------------------KILHRDM-----KAANVLITR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKLADFGLARAFSLAKNS--QPNRY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNRVVTLWYRPPELLLG--E-----------------------------RDYG-PPIDLWGAGCIMAEMWTR-----------------SPIMQG--------------------------------------------------NTEQHQLALISQL--CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD----------------------------------------------------------------------PYALDLIDKLLVLDPAQRID--------------SDDALNHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKL----------------AKIGQGT----------------FGEVFKARH--RK------------------------------------TGQKVALKKVL--MENEKEGF--------------------------PITALREIKILQLL--------------------------KHENVVNLIEICRT----------KG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIYLVFDFCE---------------HDLAGLLSN--VLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRN---------------------------------------------KILHRDM-----KAANVLITR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKLADFGLARAFSLAKNS--QPNRY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRVVTLWYRPPELLLG--E-----------------------------RDYG-PPIDLWGAGCIMAEMWTR-----------------SPIMQG--------------------------------------------------NTEQHQLALISQL--CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD----------------------------------------------------------------------PYALDLIDKLLVLDPAQRID--------------SDDALNHDFF
Activation segment
DFGLARAFSLAKNS--QPNRY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRVVTLWYRPPE
Binding pocket
AKIGQGTFGEVFKVALKKVTALREIKILQLLKENVVNLIEIYLVFDFCE_HDLAGLLSNYIHRNKILHRDMKAANVLILADFGLA
Ligand info
Orthosteric ligand
T3C
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4BCG, Chain A