4B6L Chain A
Serine/threonine-protein kinase PLK3 (PLK3)
Active — 99.8%DFG-inαC-inType1 · 9ZP
Resolution
1.9 Å
R-value
0.246
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVP
UniProt reference sequence
YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
Aligned reference sequence
YLKG----------------RLLGKGG----------------FARCYEATD--TE------------------------------------TGSAYAVKVIP--QSRVAKPHQ-------------------------REKILNEIELHRDL--------------------------QHRHIVRFSHHFEDAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYIFLELCSR--------------KSLAHIWKA--RH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR---------------------------------------------GILHRDL-----KLGNFFITE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMELKVGDFGLAARLEPPEQR--K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTICGTPNYVAPEVLLR--------------------------------QGHG-PEADVWSLGCVMYTLLCG-----------------SPPFET--------------------------------------------------ADLKETYRCIKQV--HYTLPASLS------------------------------------------------------------------------------------------------------LPARQLLAAILRASPRDRPS--------------IDQILRHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLKG----------------RLLGKGG----------------FARCYEATD--TE------------------------------------TGSAYAVKVIP--QSRVAKPHQ-------------------------REKILNEIELHRDL--------------------------QHRHIVRFSHHFEDAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIYIFLELCSR--------------KSLAHIWKA--RH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR---------------------------------------------GILHRDL-----KLGNFFITE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMELKVGDFGLAARLEPPEQR--K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTICGTPNYVAPEVLLR--------------------------------QGHG-PEADVWSLGCVMYTLLCG-----------------SPPFET--------------------------------------------------ADLKETYRCIKQV--HYTLPASLS------------------------------------------------------------------------------------------------------LPARQLLAAILRASPRDRPS--------------IDQILRHDFF
Activation segment
DFGLAARLEPPEQR--K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTICGTPNYVAPE
Binding pocket
RLLGKGGFARCYEYAVKVIKILNEIELHRDLQRHIVRFSHHYIFLELCSRKSLAHIWKAYLHQRGILHRDLKLGNFFIVGDFGLA
Ligand info
Orthosteric ligand
9ZP
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4B6L, Chain A