4AT4 Chain A
BDNF/NT-3 growth factors receptor (NTRK2)
Inactive — 0.0%DFG-outαC-outType2 · T6E
Resolution
2.36 Å
R-value
0.183
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GAMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
UniProt reference sequence
IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN
Aligned reference sequence
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLCPEQ-------------------------------DKILVAVKTLK--DASDNA----------------------------RKDFHREAELLTNL--------------------------QHEHIVKFYGVCVEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAVLMAEGNPPT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTQSQMLHIAQQIAAGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSLGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNNEVIECITQG--RVLQRPRTCP-----------------------------------------------------------------------------------------------------QEVYELMLGCWQREPHMRKN--------------IKGIHTLLQN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLC-----------------------------------KILVAVKTLK--DASDNA----------------------------RKDFHREAELLTNL--------------------------QHEHIVKFYGVCVEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAVLMA---PPT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTQSQMLHIAQQIAAGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSLGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNNEVIECITQG--RVLQRPRTCP-----------------------------------------------------------------------------------------------------QEVYELMLGCWQREPHMRKN--------------IKGIHTLLQN
Activation segment
DFGMSRDVYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPE
Binding pocket
RELGEGAFGKVFLVAVKTLDFHREAELLTNLQEHIVKFYGVIMVFEYMKHGDLNKFLRAYLASQHFVHRDLATRNCLVIGDFGMS
Ligand info
Orthosteric ligand
T6E
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4AT4, Chain A